Questions & Answers About Biotivia Suppements

Which products should I take?

If your objective is to maximize longevity, the optimal combination is either 2 Bioforte capsules or 1 Transmax along with 2 Bio Span+ daily.

If you suffer from a serious health condition and are taking resveratrol as a treatment please consult your physician regarding the correct dose.

If you are looking to maximise your protection against damaging free radicals and oxidative stress then the combination of either 2 Bioforte capsules or 1 Transmax along with 2 Bio Quench daily is ideal.

If your objective is safe and effective long term weight loss then Bio Shape is recommended. Bio Shape is most effective when supplemented with additional resveratrol in the form of 2 Bioforte capsules daily.

If physical endurance and strength along with an increase in lean body mass and a decrease in body fat is your objective then Bio Forge is the ideal choice for you. The effectiveness of Bio Forge is greatly increased by adding 1 Transmax capsule daily to your routine. This combination will result in the optimal increase in testosterone levels and IGF-1.

How should I take the products?

Resveratrol is not very water soluble therefore your body needs to produce enzymes such as bile from the liver and gall bladder to assimilate it, hence the recommendation to ingest a small amount of a healthy oil such as an Omega-3 capsule about twenty minutes before taking resveratrol. This stimulates the production of the necessary enzymes and facilitates absorption. Since our products are natural and contain no fillers which might irritate your stomach, they can be taken on an empty stomach. Resveratrol will be absorbed more easily if taken at least one hour before or after consuming a substantial meal. Our products may be taken at any time however early morning is when your body absorbs nutrients most efficiently. To prevent intracellular oxidation of the resveratrol, and this applies to many other polyphenols as well, one should take an antioxidant with one's daily resveratrol dose. Although something as simple as a Vitamin C tablet will help prevent oxidation we naturally recommend that you consider Biotivia's super fruit extract formulation, Bio Quench, as your choice of antioxidant. Bio Quench tested at an ORAC rating per gramme of over 13,500. This is the highest rating for any dry compound ever tested by Brunswick Laboratories, the inventor of the ORAC test. Polyphenols such as those contained in this supplement greatly compliment the effects of resveratrol and vice versa.

How Many Capsules Should I Take?

Dosage is a very individual choice and depends on your weight, metabolism, individual body chemistry and your primary reasons for taking the product. In general the amount you take should be in proportion to your weight. For example a 90kg pound man should take roughly twice as much as a 45kg pound woman, all other things being the same. If you are taking the product for a pre-existing condition then the dosage would be significantly higher than if you were taking resveratrol as part of a preventative regimen. As part of a daily preventative regimen the average adult (i.e. 70kg.) should take 2 Bioforte or 1 Transmax per day. This equates to about £0.70 per day for a supplement which has an extraordinarily wide range of benefits. If, however, you are treating a pre- existing condition many specialists would recommend a much higher dosage, say at least 4 times the preventative dose, or 4 Transmax a day.

What is the Difference between the Different Products. Why not just one Multi-purpose Longevity Supplement?

Transmax is a purified Trans-resveratrol isomer supplement which is identical to that used in most of the medical school trials and in vitro studies of resveratrol's health benefits. We supply this product to numerous researchers, universities, research hospitals, governments and medical schools. The US NIH and the Health Ministry of Canada are currently certifying this product as an investigational drug, IND.

Bio Span+ is a unique specially formulated combination of longevity compounds with complementary effects. It is the best and most economical way to obtain Biotivia quality and potency in a product which contains resveratrol, curcumin, silymarin and the two astragalosides of astragalus which have been shown to have telemere protective properties.

Bio Quench is an extraordinarily potent high ORAC rated antioxidant. The combination of bio-enhanced resveratrol and the concentrated extracts of the super fruits Mangosteen, Goji Berry, Pomegranate, Alpha Lipoic Acid, Grape Seed Extract and our patented apple skin extract is the best super antioxidant available anywhere.

Bioflu is the best natural protection available against the symptoms of the common cold and flu. The Black Elderberry contained in Bioflu has been shown in university double-blind human trials to reduce the duration and intensity of symptoms dramatically. Siberian Ginseng is an adaptagen which better enables your body to deal with stresses such as infection, lack of sleep, overwork and environmental stresses. Chinese Star Anise extract is a traditional Chinese and Tibetan remedy which has been used for over 2,000 years. The antioxidant value of this product alone makes it a very good value.

Bio Shape is the most potent, safe, natural weight loss product every formulated. The combination of appetite suppressants, metabolic enhancers, and purified bio-enhanced resveratrol is meant for those people looking to lose over 10 to 20 pounds in weight and improve their nutrition and protection against oxidative stress.

Bio Forge is a unique formulation of natural compounds which have been shown in multiple studies to increase endurance, reduce recovery time from intense exercise, promote lean body mass, and stimulate production of testosterone and Human Grown Factor 1. The product represents the most advanced strength and fitness supplement available without a prescription and without the adverse effects common to steroids and other banned performance enhancers.

What is the Difference Between Bioforte and Transmax Resveratrol?

Based on studies done to date virtually all of the benefits of resveratrol derive from the Trans-resveratrol isomer. Our Bioforte product has 250mg of bio-enhanced "trans-resveratrol" per all vegetable Pfizer capsule. The remaining 250mg consists of the other forms of resveratrol including glucosides of resveratrol, polydatin, emodin and other beneficial compounds naturally found in the Polygonum cuspidatum plant. That is why we call Bioforte our full spectrum resveratrol product. Transmax contains 500mg of purified "trans-resveratrol" making it laboratory grade. None of our products contain fillers, inert ingredients, or extraneous chemicals which might interfere with the purity and effectiveness of our formulations. This is an important reason why Transmax and Bioforte are used by scientists, physicians and university researchers when trying to isolate and quantify the effects of trans-resveratrol in various trials and studies. Our buyers include the top research professionals from virtually all of the respected medical schools and research institutions in the US, including Harvard, MIT, Yale, Stanford, Georgetown, University of Pittsburg and many others in Europe and the Asia.

Why were Bio Span+ and Bio Quench Developed?

Although resveratrol is the most publicised new longevity compound, it alone will not address your entire need for advanced nutrition; hence Bio Quench and Bio Span+ were developed. Bio Quench incorporates standardized high-quality extracts of the most potent super fruits. Each capsule contains more Goji Berry, Pomegranate, Mangosteen, Alpha Lipoic Acid, Grape Seed extract and an astonishingly high ORAC patented Apple skin extract, than is contained in most products offering only one of each of these ingredients. For example two Bio Quench capsules contain more antioxidant power than 1000 pints of the organic juice itself. In addition the daily dose provides more resveratrol than other standalone resveratrol products, and the entire blend is bio enhanced. This not only makes Bio Quench an incredibly potent antioxidant but also an extremely economical and convenient way to obtain the best combination of super fruit extracts along with high potency resveratrol.

Bio Span+ was designed to complement the life extension properties of resveratrol by adding concentrated polyphenols and the SirT1 Activator silymarin, along with curcumin, and the two critical astragalosides of Astralagus which are believed by many scientists to have telomere protective properties. No other product currently being manufactured compares to Bio Span+ in its potential for enhancement of longevity.

How is Bio Forge a longevity supplement? I thought this was for body builders only?

As men age, serum testosterone concentrations decrease, thepercentage of body mass that is fat increases, the percentageof lean body mass decreases, diminishment of libido, and muscle strength decreases.Many studies have shown cross-sectional (and two small studies, longitudinal)declines in total and/or free testosterone levels, withage, in men. These and other studes confirm that a significant number of men over 50 years of age will have a mean serum total testosterone level near the low end of the normal adult range. Medical experts have concluded that short term (3 months) supplementation to healthy older men who have serum free testosterone levels near or below the lower limit of normal for young adult men results in an increase in lean body mass and possibly an improvement in bone strength and density. Although Bio Forge is not a testosterone or anabolic steriod, nor does it have the potentially serious adverse effects of such anabolic compounds, it has been shown to increase the production of natural testosterone in men. Consequently, Bio Forge may also provide many of the same benefits, without the health risks, associated with direct supplementation with testosterone.

For women increased testosterone can improve bone density, mood, libido, and energy.

Does Micronization of Trans-resveratrol Improve Bioavailability?

There is no published data to support enhanced bioavailability of resveratrol through micronization. In fact quite the opposite is true. Micronization is being touted by some suppliers even though the data shows that it actually decreases total resveratrol absorption. It is true that some drugs and nutrients are enhanced by micronization however resveratrol is not one of them. Furthermore, once a micronized powder is packed into a capsule it aggregates within a short time due to the pressure and moisture and no longer is micronized. Biotivia has studied the issue of particle size in relation to free resveratrol and resveratrol metabolite bioavailability. Our conclusion, and that of other bio chemists, is that at a particle size of between 1 and 10 nanometers (micronized) a graph of blood plasma levels vs. time shows an initial spike of resveratrol concentration but one which is no higher than the maximum amplitude of the concentration curve shown with resveratrol particles of 200nm (normal resveratrol). In the case of micronized resveratrol the blood plasma level very quickly drops to a substantially lower level than that of normal resveratrol. The result is that the total amount of free resveratrol (area under the curve) existing in the blood plasma and tissues is significantly lower with micronized resveratrol than with normal resveratrol. In fact larger particle sizes actually increase bioavailability. Some researchers have hypothesized that this is because micronized resveratrol is much more easily cleared from the blood by the liver resulting in a rapid drop off of resveratrol blood plasma and tissue concentrations. So why does Sirtris use micronized resveratrol in their formulation? The answer is simple, to a bio chemist at least. Sirtris uses it to facilitate the complexing of the particles with cyclodextrine. This is necessary in a liquid product, such as his SRT-501 formulation. The increased potency of this synthetic analog of resveratrol comes at the expense of the full spectrum effects of natural resveratrol and is due to a molecular modification. It has nothing to do with micronization. Why do some suppliers use micronization? In our opinion, it has more to do with the higher prices they are charging than with the science behind it.

How does Biotivia Achieve a Two Fold Increase in Bioavailability?

Biotivia scientists have extensively researched the pharmacokinetics of resveratrol and have developed a top class product. Other companies formulate resveratrol with fillers and excipients or reduce particle size to support a claim of increased bioavailability. These suppliers have no scientific staff or laboratories and often base their formulations upon speculation by non-scientists or data that are not relevant to resveratrol. Biotivia tackles the root problem of the bioavailability of resveratrol through research by our own scientists in our own research facilities and collaboration with respected university pharmacy schools.

How do we achieve enhanced bio activity? Resveratrol goes through a step called phase I metabolism. Phase I metabolism takes place in your gut and actively attaches enzymes to resveratrol to make it non-active. In the biotech industry companies combat this type of issue in two ways. The first is to use a pro-drug. A pro-drug, which can and often is a natural plant extract, is not active itself but gets degraded into the active drug, in our case resveratrol. In essence this helps resveratrol bypass phase I metabolism and increases the potency and efficacy of our products. Another common practice among biotech companies is to use a pharmacokinetic enhancer. A pharmacokinetic enhancer will allow more resveratrol to enter your body and is an effective means of increasing resveratrol's benefits. The SirT1 activation properties of our resveratrol-based products are to a great extent a function of this enhancement process. The precise method and modifications to standard resveratrol used by Biotivia are trade secrets however in response to a challenge by one of our competitors our claim of superior bioavailability was upheld by the National Advertising Division of the National BBB after an extensive review of our evidence by their experts. Furthermore, Consumerlab found Transmax and Bioforte to be the two most potent supplements that passed their recent evaluation of resveratrol brands. This is a test that most suppliers chose not to participate in. In our clinical research we have done a one to one human study of Transmax versus pure reference standard resveratrol. We are confident that Biotivia offers truly unique and superior resveratrol-based products in terms of effective potency and bioavailability.

How Should I Store the Products?

Our products are very stable at room temperature but will not be damaged by refrigeration. Either way they will last for at least 2 years on the shelf after opening. Biotivia has pioneered the use of Active Packaging. Bioforte and Transmax are packaged using a patented oxygen absorber technology which captures the oxygen which enters the bottle when it is opened to retrieve a capsule. No other supplement maker uses this system.

Why did Biotivia Choose Not to Include Quercetin?

We have devoted quite a bit of study and research to quercetin's effect on resveratrol and resveratrol's metabolites and the issue of SirT1 activation. Our conclusion is that the most recent and best designed studies, including a study by one company that actually puts quercetin in their product, conclude that quercetin strongly inhibits the metabolites of resveratrol and suppresses SirT1 activation. Quercetin has been shown in numerous studies to interfere with the beneficial metabolites of resveratrol. These metabolites, particularly resveratrol glucuronide, resveratrol sulphate and picead possess important health properties. Studies also confirm that enterohepatic recirculation (recirculation by the liver) of these metabolites contributes significantly to the enhanced exposure of resveratrol in the tissues of mammals. Furthermore, quercetin's undesirable SirT1 suppression clearly rules it out as an ingredient in any longevity product.

If Biotivia scientists believed that quercetin would improve our products in a substantive way it would be in our interest to add it to our products. From an economic standpoint this would also benefit us, as quercetin is far less costly than the high-grade resveratrol we use in our products. A recent study by the makers of Longevinex strongly confirms our conclusion that quercetin inhibits SirT1 and possibly the other sirtuins as well. In this study a combination of resveratrol and quercetin along with the filler oat bran actually reduced SirT1 activation by a factor of 1.7 times; precisely the opposite effect one is looking for in a product designed to increase longevity.

What is Coming Next?

Biotivia has over a dozen unique products in development and testing. We expect to release the first two of these formulations within the coming 60 days. Both of these products are based upon extensive research and backed by compelling scientific evidence. Biotivia's mission is to design and formulate new and unique high potency products which address specific and important human health issues by focusing on resveratrol's clinically proven capabilities to alleviate conditions which cause human pain and suffering on a huge scale worldwide.

None of the claims made here or on any other page of this site have been evaluated by the FDA. Biotivia supplements specifically have not been proven to diagnose, prevent, cure or treat any disease. Consult your doctor if you believe that you suffer from any disease or disability.